Dictionary of DNA and Genome Technology

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  1. Dictionary of DNA and Genome Technology (Hardcover)
  2. Guide Dictionary of DNA and Genome Technology
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It offers clear explanations of terms, techniques, and tests, including commercial systems, with detailed coverage of many important procedures and methods. It explains not only well-established methodology but includes new technology and data from the latest research journals, going well beyond the remit of most science dictionaries. It includes essay-style entries on many major topics to assist newcomers to the field. Review This Product No reviews yet - be the first to create one!

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Dictionary of DNA and Genome Technology (Hardcover)

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Paul Singleton. Researchers around the world have been focused on identifying regulatory DNA to understand how the genome works.

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Guide Dictionary of DNA and Genome Technology

The findings are reported in two papers appearing in the Sept. John A. Stamatoyannopoulos, associate professor of genome sciences and medicine at the University of Washington, and senior author on both papers. We are now able to read the living human genome at an unprecedented level of detail, and to begin to make sense of the complex instruction set that ultimately influences a wide range of human biology.


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In many cases, these switches are located far away from the genes that they control. Under the right conditions, these snips occur precisely where proteins are docked at regulatory DNA. By treating cells with DNase I and analyzing the patterns of snipped DNA sequences using massively parallel sequencing technology and powerful computers, the researchers were able to create comprehensive maps of all the regulatory DNA in hundreds of different cell and tissue types.

Genome Sequence Databases

They found that of the 2. The researchers also developed a method for linking regulatory DNA to the genes it controls. Together, these findings greatly expand the understanding of how genes are controlled and how that control may differ between normal and diseased cells. These switches are scattered throughout the non-gene regions of the human genome. Having mapped the locations of the regulatory DNA switches, UW researchers wanted to know what made them tick.

The human genome contains hundreds of genes that make such proteins. However, current technologies only allow such proteins to be studied one at a time.

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They also lack the accuracy to resolve the DNA letters to which the proteins dock. As a result, most of the actual DNA words recognized by regulatory proteins in living cells were unknown. To find them, the researchers employed a simple, powerful trick that enabled them to study all the proteins at once.